• Question: how would you summarise your work and what do you think the benifits would be to society

    Asked by burnley11 to Anne, Carolyn, Joe, Mariana, Nick on 16 Mar 2010 in Categories: .
    • Photo: Nick Bradshaw

      Nick Bradshaw answered on 16 Mar 2010:


      Along with quite a lot of other people, I am trying to understand what schizophrenia actually is. It affects about 1 in every 200 people and we know what the symptoms are (hallucinations, delusions, depression etc) but until recently had no idea what the causes of it are.

      We have identified a number of different genes and proteins which, when they go wrong can cause schizophrenia in some people. We are now trying to figure out what these have in common and how they work together. If we know what they are all supposed to do, then we can figure out what would happen when they go wrong.

      And if we knew what happens when they go wrong, then we should have a pretty good idea of how to fix them and hopefully treat schizophrenia. Its a long term goal (it will probably be 10 years or so before the work starts to produce new medicines etc) but hopefully it will benefit a lot of people in the long run.

    • Photo: Joseph Devlin

      Joseph Devlin answered on 16 Mar 2010:


      My research is focused around the question: Why is it that humans have language while no other species seems to? I am specifically interested in changes to the human brain relative to other apes and monkeys that may be important for language.

      Lots of people immediately note that animals can definitely communicate and anyone whose owned a pet will agree to this. In fact, some animals communicate in pretty sophisticated ways (I’m thinking about some dolphins and whales, vervet monkeys, some singing birds, and bees, to name a few) but what is interesting, is that none of the use language — as far as we can tell (and we’ve looked pretty hard). In this sense, language is a structured communication — that is, we used phrases and sentences and paragraphs and those types of things to organize our communication and try as we might, we can’t find any evidence of that in other species. So even when people have tried to raise great apes in a human-like envirnoment with lots of communication with the ape, they never get beyond about a 2-3 year’s ability to use language. They can do some amazing things like using sign language to ask for food – Nim Chimsky would sign “me, banana, banana” but that’s not true language. In contrast, kids can’t help producing language, even when raised in the most awful environments without proper language around them. Given half a chance, a group of kids in that situation will invent their own language (called a creole) and a new language is born. This happens more often that you might expect. Just a few years ago, Nicaraguan Sign Language was born this way as was a new Bedouin language.

      But my point here is that there is massive difference between animals and humans: animals can’t seem to learn language despite our best efforts while it’s incredibly difficult to prevent kids from learning language. Why is that? What is it in our brains that makes us different from other species — particularly from other primates? That’s what I’d like to know and that’s where my research is focused.

      As for it’s importance, it’ll probably have several spin-offs. For instance, if we understood how language worked in normal healthy adults we’d have a much better understanding of how it goes wrong in patients with brain damage and that may help with assisting recovery. But even just having a clearer picture of who we are as humans and how this came about would be valuable, to my mind. We’re all curious about about ourselves and would love to know more.

    • Photo: Carolyn McGettigan

      Carolyn McGettigan answered on 16 Mar 2010:


      I use brain imaging to find out more about how our brains respond when we listen to speech and when we speak.

      There are lots of benefits to finding out how our brains work. They’re not all immediately relevant to medical treatment or therapies, but building up a good foundation of knowledge is important to support the application of advanced treatment methods in the future, for example when there are techniques for brain repair after stroke…

    • Photo: Mariana Vargas

      Mariana Vargas answered on 16 Mar 2010:


      I would like contribute to understanding how the brain stores and retrieves memories and to discover what goes wrong in the brain when we cannot longer store new memories such as in Alzheimer’s disease. The benefit to society would be that we would understand better how the brain works, and perhaps cure or even prevent dementia.

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